Prone position delays the progression of ventilator-induced lung injury in rats: does lung strain distribution play a role?
Identifieur interne : 000428 ( Main/Exploration ); précédent : 000427; suivant : 000429Prone position delays the progression of ventilator-induced lung injury in rats: does lung strain distribution play a role?
Auteurs : Franco Valenza [Italie] ; Massimiliano Guglielmi ; Micol Maffioletti ; Cecilia Tedesco ; Patrizia Maccagni ; Tommaso Fossali ; Gabriele Aletti ; Giuliana Anna Porro ; Manuela Irace ; Eleonora Carlesso ; Nadia Carboni ; Marco Lazzerini ; Luciano GattinoniSource :
- Critical care medicine [ 0090-3493 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Contrainte mécanique (MeSH), Décubitus ventral (MeSH), Mâle (MeSH), Poumon (imagerie diagnostique), Poumon (physiopathologie), Rat Sprague-Dawley (MeSH), Rats (MeSH), Syndrome de détresse respiratoire de l'adulte (imagerie diagnostique), Syndrome de détresse respiratoire de l'adulte (physiopathologie), Syndrome de détresse respiratoire de l'adulte (thérapie), Syndrome de détresse respiratoire de l'adulte (étiologie), Tomodensitométrie (MeSH), Ventilation artificielle (effets indésirables), Ventilation artificielle (méthodes), Évolution de la maladie (MeSH).
- MESH :
- effets indésirables : Ventilation artificielle.
- imagerie diagnostique : Poumon, Syndrome de détresse respiratoire de l'adulte.
- méthodes : Ventilation artificielle.
- physiopathologie : Poumon, Syndrome de détresse respiratoire de l'adulte.
- thérapie : Syndrome de détresse respiratoire de l'adulte.
- étiologie : Syndrome de détresse respiratoire de l'adulte.
- Animaux, Contrainte mécanique, Décubitus ventral, Mâle, Rat Sprague-Dawley, Rats, Tomodensitométrie, Évolution de la maladie.
English descriptors
- KwdEn :
- Animals (MeSH), Disease Progression (MeSH), Lung (diagnostic imaging), Lung (physiopathology), Male (MeSH), Prone Position (MeSH), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Respiration, Artificial (adverse effects), Respiration, Artificial (methods), Respiratory Distress Syndrome, Adult (diagnostic imaging), Respiratory Distress Syndrome, Adult (etiology), Respiratory Distress Syndrome, Adult (physiopathology), Respiratory Distress Syndrome, Adult (therapy), Stress, Mechanical (MeSH), Tomography, X-Ray Computed (MeSH).
- MESH :
- adverse effects : Respiration, Artificial.
- diagnostic imaging : Lung, Respiratory Distress Syndrome, Adult.
- etiology : Respiratory Distress Syndrome, Adult.
- methods : Respiration, Artificial.
- physiopathology : Lung, Respiratory Distress Syndrome, Adult.
- therapy : Respiratory Distress Syndrome, Adult.
- Animals, Disease Progression, Male, Prone Position, Rats, Rats, Sprague-Dawley, Stress, Mechanical, Tomography, X-Ray Computed.
Abstract
OBJECTIVE
To investigate if prone position delays the progression of experimental ventilator-induced lung injury, possibly due to a more homogeneous distribution of strain within lung parenchyma.
DESIGN
Prospective, randomized, controlled trial.
SETTING
Animal laboratory of a university hospital.
SUBJECTS
Thirty-five Sprague Dawley male rats (weight 257 +/- 45 g).
INTERVENTIONS
Mechanical ventilation in either supine or prone position and computed tomography scan analysis.
MEASUREMENTS
: Animals were ventilated in supine (n = 15) or prone (n = 15) position until a similar ventilator-induced lung injury was reached. To do so, experiments were interrupted when respiratory system elastance was 150% of baseline. Ventilator-induced lung injury was assessed as lung wet-to-dry ratio and histology. Time to reach lung injury was considered as a main outcome measure. In five additional animals, computed tomography scans (GE Light Speed QX/I, thickness 1.25 mm, interval 0.6 mm, 100 MA, 100 Kv) were randomly taken at end-expiration and end-inspiration in both positions, and quantitative analysis was performed. Data are shown as mean +/- sd.
MEASUREMENTS AND MAIN RESULTS
Similar ventilator-induced lung injury was reached (respiratory system elastance, wet-to-dry ratio, and histology). The time taken to achieve the target ventilator-induced lung injury was longer with prone position (73 +/- 37 mins vs. 112 +/- 42, supine vs. prone, p = .011). Computed tomography scan analysis performed before lung injury revealed that at end-expiration, the lung was wider in prone position (p = .004) and somewhat shorter (p = .09), despite similar lung volumes (p = .455). Lung density along the vertical axis increased significantly only in supine position (p = .002). Lung strain was greater in supine as opposed to prone position (width strain, 7.8 +/- 1.8% vs. 5.6 +/- 0.9, supine vs. prone, p = .029).
CONCLUSIONS
Prone position delays the progression of ventilator-induced lung injury. Computed tomography scan analysis suggests that a more homogeneous distribution of strain may be implicated in the protective role of prone position against ventilator-induced lung injury.
DOI: 10.1097/01.ccm.0000150660.45376.7c
PubMed: 15699840
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Sforza 35, 20122 Milano, Italy. franco.valenza@unimi.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Università degli Studi di Milano, Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano-IRCCS, Via F. Sforza 35, 20122 Milano</wicri:regionArea><wicri:noRegion>20122 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Guglielmi, Massimiliano" sort="Guglielmi, Massimiliano" uniqKey="Guglielmi M" first="Massimiliano" last="Guglielmi">Massimiliano Guglielmi</name></author><author><name sortKey="Maffioletti, Micol" sort="Maffioletti, Micol" uniqKey="Maffioletti M" first="Micol" last="Maffioletti">Micol Maffioletti</name></author><author><name sortKey="Tedesco, Cecilia" sort="Tedesco, Cecilia" uniqKey="Tedesco C" first="Cecilia" last="Tedesco">Cecilia Tedesco</name></author><author><name sortKey="Maccagni, Patrizia" sort="Maccagni, Patrizia" uniqKey="Maccagni P" first="Patrizia" last="Maccagni">Patrizia Maccagni</name></author><author><name sortKey="Fossali, Tommaso" sort="Fossali, Tommaso" uniqKey="Fossali T" first="Tommaso" last="Fossali">Tommaso Fossali</name></author><author><name sortKey="Aletti, Gabriele" sort="Aletti, Gabriele" uniqKey="Aletti G" first="Gabriele" last="Aletti">Gabriele Aletti</name></author><author><name sortKey="Porro, Giuliana Anna" sort="Porro, Giuliana Anna" uniqKey="Porro G" first="Giuliana Anna" last="Porro">Giuliana Anna Porro</name></author><author><name sortKey="Irace, Manuela" sort="Irace, Manuela" uniqKey="Irace M" first="Manuela" last="Irace">Manuela Irace</name></author><author><name sortKey="Carlesso, Eleonora" sort="Carlesso, Eleonora" uniqKey="Carlesso E" first="Eleonora" last="Carlesso">Eleonora Carlesso</name></author><author><name sortKey="Carboni, Nadia" sort="Carboni, Nadia" uniqKey="Carboni N" first="Nadia" last="Carboni">Nadia Carboni</name></author><author><name sortKey="Lazzerini, Marco" sort="Lazzerini, Marco" uniqKey="Lazzerini M" first="Marco" last="Lazzerini">Marco Lazzerini</name></author><author><name sortKey="Gattinoni, Luciano" sort="Gattinoni, Luciano" uniqKey="Gattinoni L" first="Luciano" last="Gattinoni">Luciano Gattinoni</name></author></analytic><series><title level="j">Critical care medicine</title><idno type="ISSN">0090-3493</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Disease Progression (MeSH)</term><term>Lung (diagnostic imaging)</term><term>Lung (physiopathology)</term><term>Male (MeSH)</term><term>Prone Position (MeSH)</term><term>Rats (MeSH)</term><term>Rats, Sprague-Dawley (MeSH)</term><term>Respiration, Artificial (adverse effects)</term><term>Respiration, Artificial (methods)</term><term>Respiratory Distress Syndrome, Adult (diagnostic imaging)</term><term>Respiratory Distress Syndrome, Adult (etiology)</term><term>Respiratory Distress Syndrome, Adult (physiopathology)</term><term>Respiratory Distress Syndrome, Adult (therapy)</term><term>Stress, Mechanical (MeSH)</term><term>Tomography, X-Ray Computed (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Contrainte mécanique (MeSH)</term><term>Décubitus ventral (MeSH)</term><term>Mâle (MeSH)</term><term>Poumon (imagerie diagnostique)</term><term>Poumon (physiopathologie)</term><term>Rat Sprague-Dawley (MeSH)</term><term>Rats (MeSH)</term><term>Syndrome de détresse respiratoire de l'adulte (imagerie diagnostique)</term><term>Syndrome de détresse respiratoire de l'adulte (physiopathologie)</term><term>Syndrome de détresse respiratoire de l'adulte (thérapie)</term><term>Syndrome de détresse respiratoire de l'adulte (étiologie)</term><term>Tomodensitométrie (MeSH)</term><term>Ventilation artificielle (effets indésirables)</term><term>Ventilation artificielle (méthodes)</term><term>Évolution de la maladie (MeSH)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lung</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Ventilation artificielle</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Poumon</term><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Ventilation artificielle</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Poumon</term><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lung</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Progression</term><term>Male</term><term>Prone Position</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Stress, Mechanical</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Contrainte mécanique</term><term>Décubitus ventral</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Tomodensitométrie</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To investigate if prone position delays the progression of experimental ventilator-induced lung injury, possibly due to a more homogeneous distribution of strain within lung parenchyma.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Prospective, randomized, controlled trial.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING</b></p><p>Animal laboratory of a university hospital.</p></div><div type="abstract" xml:lang="en"><p><b>SUBJECTS</b></p><p>Thirty-five Sprague Dawley male rats (weight 257 +/- 45 g).</p></div><div type="abstract" xml:lang="en"><p><b>INTERVENTIONS</b></p><p>Mechanical ventilation in either supine or prone position and computed tomography scan analysis.</p></div><div type="abstract" xml:lang="en"><p><b>MEASUREMENTS</b></p><p>: Animals were ventilated in supine (n = 15) or prone (n = 15) position until a similar ventilator-induced lung injury was reached. To do so, experiments were interrupted when respiratory system elastance was 150% of baseline. Ventilator-induced lung injury was assessed as lung wet-to-dry ratio and histology. Time to reach lung injury was considered as a main outcome measure. In five additional animals, computed tomography scans (GE Light Speed QX/I, thickness 1.25 mm, interval 0.6 mm, 100 MA, 100 Kv) were randomly taken at end-expiration and end-inspiration in both positions, and quantitative analysis was performed. Data are shown as mean +/- sd.</p></div><div type="abstract" xml:lang="en"><p><b>MEASUREMENTS AND MAIN RESULTS</b></p><p>Similar ventilator-induced lung injury was reached (respiratory system elastance, wet-to-dry ratio, and histology). The time taken to achieve the target ventilator-induced lung injury was longer with prone position (73 +/- 37 mins vs. 112 +/- 42, supine vs. prone, p = .011). Computed tomography scan analysis performed before lung injury revealed that at end-expiration, the lung was wider in prone position (p = .004) and somewhat shorter (p = .09), despite similar lung volumes (p = .455). Lung density along the vertical axis increased significantly only in supine position (p = .002). Lung strain was greater in supine as opposed to prone position (width strain, 7.8 +/- 1.8% vs. 5.6 +/- 0.9, supine vs. prone, p = .029).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Prone position delays the progression of ventilator-induced lung injury. Computed tomography scan analysis suggests that a more homogeneous distribution of strain may be implicated in the protective role of prone position against ventilator-induced lung injury.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15699840</PMID><DateCompleted><Year>2005</Year><Month>03</Month><Day>16</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>06</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0090-3493</ISSN><JournalIssue CitedMedium="Print"><Volume>33</Volume><Issue>2</Issue><PubDate><Year>2005</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Critical care medicine</Title></Journal><ArticleTitle>Prone position delays the progression of ventilator-induced lung injury in rats: does lung strain distribution play a role?</ArticleTitle><Pagination><MedlinePgn>361-7</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate if prone position delays the progression of experimental ventilator-induced lung injury, possibly due to a more homogeneous distribution of strain within lung parenchyma.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Prospective, randomized, controlled trial.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Animal laboratory of a university hospital.</AbstractText><AbstractText Label="SUBJECTS" NlmCategory="METHODS">Thirty-five Sprague Dawley male rats (weight 257 +/- 45 g).</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Mechanical ventilation in either supine or prone position and computed tomography scan analysis.</AbstractText><AbstractText Label="MEASUREMENTS" NlmCategory="METHODS">: Animals were ventilated in supine (n = 15) or prone (n = 15) position until a similar ventilator-induced lung injury was reached. To do so, experiments were interrupted when respiratory system elastance was 150% of baseline. Ventilator-induced lung injury was assessed as lung wet-to-dry ratio and histology. Time to reach lung injury was considered as a main outcome measure. In five additional animals, computed tomography scans (GE Light Speed QX/I, thickness 1.25 mm, interval 0.6 mm, 100 MA, 100 Kv) were randomly taken at end-expiration and end-inspiration in both positions, and quantitative analysis was performed. Data are shown as mean +/- sd.</AbstractText><AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">Similar ventilator-induced lung injury was reached (respiratory system elastance, wet-to-dry ratio, and histology). The time taken to achieve the target ventilator-induced lung injury was longer with prone position (73 +/- 37 mins vs. 112 +/- 42, supine vs. prone, p = .011). Computed tomography scan analysis performed before lung injury revealed that at end-expiration, the lung was wider in prone position (p = .004) and somewhat shorter (p = .09), despite similar lung volumes (p = .455). Lung density along the vertical axis increased significantly only in supine position (p = .002). Lung strain was greater in supine as opposed to prone position (width strain, 7.8 +/- 1.8% vs. 5.6 +/- 0.9, supine vs. prone, p = .029).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Prone position delays the progression of ventilator-induced lung injury. Computed tomography scan analysis suggests that a more homogeneous distribution of strain may be implicated in the protective role of prone position against ventilator-induced lung injury.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Valenza</LastName><ForeName>Franco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Università degli Studi di Milano, Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano-IRCCS, Via F. Sforza 35, 20122 Milano, Italy. franco.valenza@unimi.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guglielmi</LastName><ForeName>Massimiliano</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Maffioletti</LastName><ForeName>Micol</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Tedesco</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Maccagni</LastName><ForeName>Patrizia</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Fossali</LastName><ForeName>Tommaso</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Aletti</LastName><ForeName>Gabriele</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Porro</LastName><ForeName>Giuliana Anna</ForeName><Initials>GA</Initials></Author><Author ValidYN="Y"><LastName>Irace</LastName><ForeName>Manuela</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Carlesso</LastName><ForeName>Eleonora</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Carboni</LastName><ForeName>Nadia</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Lazzerini</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Gattinoni</LastName><ForeName>Luciano</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016420">Comment</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Crit Care Med</MedlineTA><NlmUniqueID>0355501</NlmUniqueID><ISSNLinking>0090-3493</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentOn"><RefSource>Crit Care Med. 2005 Feb;33(2):453-5</RefSource><PMID Version="1">15699858</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016684" MajorTopicYN="N">Prone Position</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013314" MajorTopicYN="N">Stress, Mechanical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>2</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>3</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>2</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15699840</ArticleId><ArticleId IdType="pii">00003246-200502000-00012</ArticleId><ArticleId IdType="doi">10.1097/01.ccm.0000150660.45376.7c</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Aletti, Gabriele" sort="Aletti, Gabriele" uniqKey="Aletti G" first="Gabriele" last="Aletti">Gabriele Aletti</name><name sortKey="Carboni, Nadia" sort="Carboni, Nadia" uniqKey="Carboni N" first="Nadia" last="Carboni">Nadia Carboni</name><name sortKey="Carlesso, Eleonora" sort="Carlesso, Eleonora" uniqKey="Carlesso E" first="Eleonora" last="Carlesso">Eleonora Carlesso</name><name sortKey="Fossali, Tommaso" sort="Fossali, Tommaso" uniqKey="Fossali T" first="Tommaso" last="Fossali">Tommaso Fossali</name><name sortKey="Gattinoni, Luciano" sort="Gattinoni, Luciano" uniqKey="Gattinoni L" first="Luciano" last="Gattinoni">Luciano Gattinoni</name><name sortKey="Guglielmi, Massimiliano" sort="Guglielmi, Massimiliano" uniqKey="Guglielmi M" first="Massimiliano" last="Guglielmi">Massimiliano Guglielmi</name><name sortKey="Irace, Manuela" sort="Irace, Manuela" uniqKey="Irace M" first="Manuela" last="Irace">Manuela Irace</name><name sortKey="Lazzerini, Marco" sort="Lazzerini, Marco" uniqKey="Lazzerini M" first="Marco" last="Lazzerini">Marco Lazzerini</name><name sortKey="Maccagni, Patrizia" sort="Maccagni, Patrizia" uniqKey="Maccagni P" first="Patrizia" last="Maccagni">Patrizia Maccagni</name><name sortKey="Maffioletti, Micol" sort="Maffioletti, Micol" uniqKey="Maffioletti M" first="Micol" last="Maffioletti">Micol Maffioletti</name><name sortKey="Porro, Giuliana Anna" sort="Porro, Giuliana Anna" uniqKey="Porro G" first="Giuliana Anna" last="Porro">Giuliana Anna Porro</name><name sortKey="Tedesco, Cecilia" sort="Tedesco, Cecilia" uniqKey="Tedesco C" first="Cecilia" last="Tedesco">Cecilia Tedesco</name></noCountry><country name="Italie"><noRegion><name sortKey="Valenza, Franco" sort="Valenza, Franco" uniqKey="Valenza F" first="Franco" last="Valenza">Franco Valenza</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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